A DHL cargo plane skidded off a runway and ended up on a road near the airport in Bergamo early Friday, the Italian Civil Aviation Authority said.
The plane, a Boeing 737-400, lost control during the landing, went off the runway, plowed through a fence and crashed into the nearby road.
The captain and first officer were unharmed, according to a statement from the Italian authorities.
Dramatic pictures of the incident showed the aircraft protruding well into the road with debris shattered on the ground. Workers at the scene estimated that it would take hours to clean up the scene, CNN affiliate Rai News 24 reported.
Flight BCS 7332 had departed from Paris Charles de Gaulle Airport and landed early Friday morning at the Orio al Serio Airport in northern Italy.
The airport has since re-opened, but the incident resulted in several delayed or canceled flights.